Jarrod Dalton Research Program

Research

Overview

Dr. Dalton has conducted National Institutes of Health-funded population health research continuously since 2013, including a National Institute on Aging-funded collaboration between Cleveland Clinic and MetroHealth System to understand neighborhood-level variation in cardiovascular risk. He also co-leads an National Heart, Lung, and Blood Institute-funded project to develop more equitable policies for lung transplant allocation through the application of robust statistical and simulation-based modeling approaches.  Dr. Dalton has over 100 peer-reviewed scientific articles, and is a member of the editorial board for Medical Decision Making. His scientific contributions have earned the designation of Top-Ranked Abstract at 3 recent Annual Meetings of the Society for Medical Decision Making (SMDM). He received the 2018 SMDM Outstanding Paper by a Young Investigator Award for his Annals of Internal Medicine article. 

In the News

What Are Digital Twins and How Can They Be Used In Healthcare? | HealthTech

A new approach to lung transplants prioritization could curb deaths | Crain’s Cleveland Business

Cleveland Clinic model for lung transplant prioritization could reduce deaths, study finds | Ideastream Public Media

Cleveland Clinic receives $3M grant to develop model aimed at reducing health care disparities | Crain’s Cleveland Business 

Selected Publications

 1)    Assessing and improving accuracy of clinical prediction models implemented in guidelines and policy.    

1.  Dalton JE, Perzynski AT, Zidar, DA, Rothberg MB, Coulton CJ, Milinovich AT, Einstadter D, Karichu JK, and Dawson NV (2017). Accuracy of cardiovascular risk prediction varies by neighborhood socioeconomic position: a retrospective cohort study. Annals of Internal Medicine 167(7): 456-64. PMC6435027.  
2.  Dalton JE, Rothberg MB, Dawson NV, Krieger NI, Zidar DA and Perzynski AT (2020). Failure of traditional clinical risk factors to adequately predict atherosclerotic cardiovascular events in patients over age 65. Journal of the American Geriatrics Society 68(4):754-761. PMC6902755  
3.  Dalton JE*, Lehr CJ*, Gunsalus PR, Mourany L and Valapour M (2022). Refining the lung allocation score models fails to improve discrimination performance. CHEST 163(1):152-163. PMCID: in process.  
4. Dalton JE, Lehr CJ, Gunsalus PR, Mourany L, and Valapour M (2023). Miscalibration of lung allocation models leads to inaccurate waitlist mortality predictions. American Journal of Transplantation 23(1):72-77. PMCID: in process.

 2)    Adapting electronic health records for population health research and longitudinal studies in aging.  

1.  Dalton JE, Dawson NV, Sessler DI, Schold JD, Love TE, and Kattan MW (2016).  Empirical treatment effectiveness models for binary outcomes. Medical Decision Making 36(1):101-14. PMC4596743.  
2.  Gunzler DD, Perzynski AT, Dawson NV, Kauffman  K, Liu J, and Dalton JE (2019). Risk-period-cohort approach for averting identification problems in longitudinal models. PLoS One 14(7), p.e0219399. PMC6620014.  
3.  Taksler GB, Dalton JE, Perzynski AT, Rothberg MB, Milinovich A, Krieger NI, Dawson NV, Roach MJ, Lewis MD, Einstadter D (2021). Opportunities, pitfalls, and alternatives in adapting electronic health records for health services research. Medical Decision Making. 41(2):133-42. PMC7878193.  
4. Dalton JE, Pfoh ER, Dawson NV, Mourany L, Becerril A, Gunzler DD, Berg KA, Einstadter D, Krieger NI, Perzynski AT (2022). Evaluating and Modeling Neighborhood Diversity and Health Using Electronic Health Records. Medical Decision Making. 42(8):1027-1040. PMC9586466.

 3)    Health services research studies evaluating and optimizing clinical decisions and programs.

1.    Dalton JE, Glance LG, Mascha EJ, Ehrlinger J, Chamoun N, Sessler DI (2013). Impact of present-on-admission indicators on risk-adjusted hospital mortality measurement. Anesthesiology 118(6):1298-1306.   
2.  Dalton JE, Zidar DA, Udeh BL, Patel MR, Schold JD, and Dawson NV (2016). Practice variation among hospitals in revascularization therapy and its association with procedure-related mortality. Medical Care54(6): 623-31. PMC4865419.  
3.  Dalton JE, Gunzler DD, Jain V, Perzynski AT, Dawson NV, Einstadter D, Tarabichi Y, Imrey P, Lewis M, Kattan MW, Yao J, Taksler G, Berg KA, Krieger NI, Kaelber D, Jehi L and Kalra A (2021). Mechanisms of socioeconomic differences in COVID-19 screening and hospitalizations. PLoS One 16(8): e0255343. PMC8341486  
4.  Pfoh ER, Dalton J, Jones R, Rothberg MB. Long-term Outcomes of a 1-year Hypertension Quality Improvement Initiative in a Large Health System. Medical Care. 2023:10-97. in process.  

4)    Methods and technologies for quantitative modeling in population health and clinical systems science. 

1.  Dalton JE and Nutter B (2015). HydeNet: Hybrid Bayesian networks using R and JAGS. R package version 0.9.0. URL: http://CRAN.R-project.org/package=HydeNet.   
2. Krieger NI, Wang C, Dalton JE, Perzynski AT (2018). sociome: Helping researchers to operationalize social determinants of health data. R package version 0.4.0. https://github.com/NikKrieger/sociome. 
3.  Berg KA, Dalton JE, Gunzler DD, Coulton CJ, Freedman DA, Krieger NI, Dawson NV, Perzynski AT (2021). The ADI-3: A revised neighborhood risk index of the social determinants of health over time and place. Health Services and Outcomes Research Methodology 1-24.  
4.  Krieger NI and Dalton JE (2019). Dynamically adaptive probabilistic systems (daps). R package version 0.1.0. URL: http://github.com/nikkrieger/daps.   

5)    Other studies of variation in disease burden, risk and outcomes within and among specific populations. 

1.  Dalton JE, Kurz A, Turan A, Mascha EJ, Sessler DI, Saager L (2011). Development and validation of a risk quantification index for 30-day postoperative mortality and morbidity in noncardiac surgical patients. Anesthesiology 114(6):1336-1344.   
2.  Zidar DA, Al-Kindi SG, Liu Y, Krieger NI, Perzynski AT, Osnard M, Nmai C, Anthony DD, Lederman MM, Freeman ML, Bonomo RA, Simon DI and Dalton JE (2019). Association of lymphopenia with risk of mortality among adults in the US general population. JAMA Network Open 2(12):e1916526. PMC6902755  
3.  Bensken, WP, Krieger, NI, Berg, KA, Einstadter, D, Dalton, JE*, Perzynski, AT* (2022). Health Status and Chronic Disease Burden of the Homeless Population: An Analysis of Two Decades of Multi-Institutional Electronic Medical Records. Journal of Health Care for the Poor and Underserved 32(3):1619-34. PMC8477616.  
4.  Becerril A, Pfoh ER, Hashmi AZ, Mourany L, Gunzler DD, Berg KA, Krieger NI, Krishnan K, Moore SE, Kahana E, Dawson NV, Shamakian LL, Campbell JW, Perzynski AT*, Dalton JE*. Racial, ethnic and neighborhood socioeconomic differences in incidence of dementia: a regional retrospective cohort study. Journal of the American Geriatrics Society (accepted) PMCID: in process.