Raed Dweik, MD
Staff
Chairman, Respiratory Institute
Location: Cleveland Clinic Main Campus
Research
Biography
Raed Dweik, MD, MBA is the Chair of Cleveland Clinic’s Respiratory Institute (RI) which has over 650 employees including 172 faculty members, 72 advanced practice providers and 49 fellows in four departments: Pulmonary Medicine, Critical Care Medicine, Infectious Disease, and Allergy/Immunology. The clinical activities of the RI are conducted at Cleveland Clinic’s main campus, as well as eight Cleveland Clinic Health System hospitals and 15 freestanding multispecialty outpatient facilities. Annually, we perform over 200,000 outpatient visits, 60,000 pulmonary function tests, 5,000 bronchoscopies, and 120 lung transplants. We have a daily hospital census of over 350 inpatient beds including over 150 patients in medical intensive care units (MICUs) across the system. In addition to providing general pulmonary, critical care, infectious disease and allergy services, the RI provides advanced subspecialty services that attract patients from throughout the United States and several countries. Over 20 percent of the Institute’s patients come from outside of Northeast Ohio. The educational activities of the RI include five fellowship programs in pulmonary and critical care (24 fellows), critical care (12 total fellows), infectious disease (8 fellows), allergy and clinical immunology (4 fellows), and advanced interventional bronchoscopy (1 fellow). The RI conducts a broad spectrum of research activities across the spectrum of basic, translational, and clinical research (including multicenter clinical trials). The research is supported by over 60 federal grants, 50 industry sponsored trials, and various foundation awards.
Dr. Dweik's clinical interests include pulmonary hypertension, asthma, chronic beryllium disease and critical care and he regularly attends in the medical intensive care unit (MICU). He is board certified in internal medicine, pulmonary disease and critical care medicine and has been listed in The Best Doctors in America since 2005.
Dr. Dweik is Professor of Medicine at Cleveland Clinic Lerner College of Medicine and has a joint appointment in the Lerner Research Institute (LRI) with continuous funding from the NIH since 2002. He established a Research Center of Excellence in Pulmonary Vascular Disease including a patient registry, a human sample biorepository and an animal model core. He was the recipient of the Cleveland Clinic Outstanding Innovation in Translational Medicine Award and a Third Frontier Award from the state of Ohio for his pioneering work in exhaled breath analysis in lung and systemic disease. He has published over 250 peer reviewed manuscripts and book chapters and serves on several journal editorial boards, National Institutes of Health (NIH) review panels and American Thoracic Society (ATS), American Heart Association (AHA), and Association of American Medical Colleges (AAMC) committees.
Dr. Dweik is the recipient of many teaching awards including the Cleveland Clinic Distinguished Teacher Award from the Internal Medicine Residency Program for five times, the Teacher of the Year Award from the Pulmonary Fellowship Program and the Scholarship in Teaching Award from Case Western Reserve University. He is Director of the KL2 program of the Cleveland Clinical and Translational Science Collaborative (CTSC), a member of the admissions committee at CCLCM, and past chair of the Committee on Advancement, Promotion and Tenure (CAPT) at Case Western Reserve University School of Medicine.
Dr. Dweik has served on the Board of Governors, Board of Trustees and Board of Directors of the Cleveland Clinic Health System and chairs the system's Innovation Management and Conflict of Interest committee (IM&COI), the routine Capital Review Committee (CRC) and the strategic capital Advisory Team (AT).
Dr. Dweik is a Fellow of the American College of Physicians (FACP), the Royal College of Physicians of Canada (FRCPC), the American College of Chest Physicians (FCCP), the Society of Critical Care Medicine (FCCM), the American Thoracic Society (ATSF), the American Heart Association (FAHA), the Pulmonary Vascular Research Institute (PVRI), and a founding member of the International Association for Breath Research (IABR).
After receiving his medical degree from the University of Jordan Faculty of Medicine, Dr. Dweik completed his internship and residency in internal medicine at Miami Valley Hospital and Wright State University in Dayton, OH. He completed his fellowship in pulmonary and critical care medicine at Cleveland Clinic. He earned an MBA from Case Western Reserve University in 2017.
Education & Professional Highlights
Education & Fellowships
Graduate School - Case Western Reserve University Weatherhead School of Management
MBA
Cleveland, OH USA
2017
Fellowship - Cleveland Clinic
Pulmonary Disease/Critical Car
Cleveland, OH USA
1996
Residency - Wright State University
Internal Medicine
Dayton, OH USA
1993
Internship - Miami Valley Hospital
Internal Medicine
Dayton, OH USA
1990
Internship - Jordan University Hospital
Rotating
Amman,
1989
Medical Education - University of Jordan Faculty of Medicine
Amman, Jordan
1988
Professional Highlights
-
Executive:
2015 Member, Cleveland Clinic Board of Directors Cleveland Clinic, Cleveland, OH - 2014-15 Member, Cleveland Clinic Board of Trustees Cleveland Clinic, Cleveland, OH
- 2014- Chair, Innovation Management and Conflict of Interest, Cleveland Clinic Health System
- 2011-15 Elected member: Cleveland Clinic Board of Governors
- 2008-2013 Member, Respiratory Institute Executive Physician Committee
- 2008-2013 Member, Respiratory Institute Administrative Council, Cleveland Clinic
Clinical and Academic:
2016- Chair, Documents Development and implementation Committee (DDIC), American Thoracic Society (ATS) - 2014- Director, KL2 Program and Chair, KL2 Steering Committee / Cleveland Clinical and Translational Science Collaborative (CTSC), Case Western Reserve University SOM
- 2014-15 Chair, Committee on Appointment, Promotion, and Tenure (CAPT), Case Western Reserve University School of Medicine (CWRU-SOM)
- 2014- Chair, Cleveland Clinic Standing Committee on Research Conduct and Quality
- 2015- Chair, Cardiorenal and Lung Peer Review Committee, American Heart Association (AHA)
- 2015- Reviewer, Respiratory Integrative Biology and Translational Research, RIBT Study section, National Heart Lung and Blood Institute (NHLBI) - NIH
- 2009- Scientific Advisory Board (SAB) Member: Mid-Infrared Technologies for Health and the Environment, A National Science Foundation (NSF) – Engineering Research Center at Princeton University and Partners
- 2008-2012: Third Frontier Award: Ohio Department of Development
- 2005- Founding Member: International Association for Breath Research (IABR)
- 2005-2010 Member / Reviewer, Special Emphasis Panel, Mentored Clinical Scientist Development Award (K08), National Heart Lung and Blood Institute (NHLBI), National Institutes of Health (NIH)
- 2004- 2009 Member, Special Emphasis Panel, Mentored Patient Oriented Research Career Development Awards (K18, K23, K24 and K25) National Heart Lung and Blood Institute (NHLBI), National Institutes of Health (NIH)
- 2003- Admissions Committee Member, Cleveland Clinic Lerner College of Medicine of CWRU
Certifications
- Internal Medicine
- Internal Medicine - Pulmonary Disease
- Internal Medicine - Critical Care Medicine
Awards & Honors
- Listed in "Best Doctors in America": 2005- Present
- Distinguished Teacher Award Internal Medicine Residency Program: 2000-01, 2003-04, 2004-05, 2006-07, 2007-08.
- Teacher of the Year Award Pulmonary Fellowship Program: 2006-2007
- Cleveland Clinic Foundation Innovator Award 2004
- Lerner Research Institute STAR Award 2010
Innovations & Patents
- Exhaled Breath Testing
Memberships
- American College of Physicians, Fellow (FACP)
- American College of Chest Physicians, Fellow (FCCP)
- Royal College of Physicians of Canada, Fellow (FRCPC)
- American Heart Association (AHA), Fellow (FAHA)
- Society of Critical Care Medicine (SCCM), Fellow (FCCM)
- Pulmonary Vascular Research Institute (PVRI), Fellow
- American Thoracic Society (ATS), Member
- American Association for the Advancement of Science, Member
- American Physiological Society, Member
- International Association for Breath Research, Founding Member
Research
Nitric oxide (NO) is endogenously synthesized by nitric oxide synthases (NOSs) which convert L-arginine to L-citrulline and NO in the presence of oxygen and several cofactors. Once produced, NO is freely diffusible and enters target cells and into the airway and can be detected in exhaled breath of all humans. NO is formed in high concentrations in the upper respiratory tract (nasopharynx and paranasal sinuses). Our studies have also conclusively demonstrated that the lower respiratory tract is a significant source of NO in exhaled breath. We have also demonstrated that endogenous NO levels in the lung change rapidly in direct proportion to inspired oxygen which strongly supports a critical role for NO as mediator of ventilation-perfusion coupling in the lung. NO also plays a major role in the pathophysiology of pulmonary hypertension (PH), a group of diseases characterized by high pulmonary artery pressures and pulmonary vascular resistance. Our studies have shown that patients with idiopathic pulmonary arterial hypertension (IPAH, previously known as primary pulmonary hypertension or PPH) have low levels of NO in their exhaled breath that increase after initiation of vasodilator therapy. The goal of our current studies is to understand the role of nitric oxide (and other markers in exhaled breath) in lung physiology and in the pathophysiology of lung diseases like pulmonary hypertension and asthma.
Our Team
Selected Publications
View publications for Raed Dweik, MD
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Dweik RA, et.al. NO synthesis in the lung. JCI 1998. Dweik RA, et.al. NO Chemical Events in the Human Airway During Antigen-Induced Asthmatic Response. PNAS 2001. Dweik RA. Pulmonary hypertension and the search for the selective pulmonary vasodilator. Lancet 2002.Dweik RA. Nitric oxide, hypoxia, and superoxide: the good, the bad, and the ugly! Thorax 2005.(Dweik RA, contributing author). ATS Recommendations for Standardized Procedures for Exhaled Nitric Oxide 2005. AJRCCM 2005.Dweik RA. The lung in the balance: arginine, methylated arginines, and nitric oxide. AJP Lung 2007.
Careers
Research News
Critical federal support will enable trainees to pursue greater research efforts into basic science and critical care medicine.
Although the exact etiology of idiopathic PAH is unclear, well-characterized imbalances in vascular homeostasis have been identified by researchers at Cleveland Clinic.